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DIANABOL (or DBOL), a common brand name for methandienone (also known as methandrostenolone or methandienone) is an androgen steroid belonging to the animal steroids category. DBOL is likely one of the most favourite steroids of many athletes, bodybuilders and powerlifters as they provide the best possible impacts with the least possible issue. Various ads have been made about the potency of this anabolic steroid. They are popularly used among bodybuilders and powerlifters due to their strength and muscle-enhancing capacities. They are significantly fast and one can notice observations in a few weeks and are widely used to enhance the athlete’s physique and performance. With a full regimen of less than $100, this steroid is considered to be one of the cheapest steroids in the market. Many ads are there on social media which exhibit the power and features of these steroids. Dianabol may exhibit potentially dangerous impacts when administered without the advice of a registered medical professional. So despite its popularity among bodybuilders, Dianobol is considered a controlled substance (Schedule III) in the United States and the United Kingdom. However, according to the information in Wikipedia in certain countries like Mexico, they are legal and can be bought readily over the counter. Various ads exist which tell about where to get this steroid.
Utilized by Top Bodybuilders
It is a plain and simple steroid, widely used by professional bodybuilders, athletes and powerlifters in a location. According to research information, it is an oral drug (tablet) and is not advised to be administered as an injection. It is usually stacked up with other similar steroids to obtain the best of benefits. This steroid is considered to be an agonist of the Androgen Receptor (AR) and the biological target of androgens like testosterone and dihydrotestosterone (DHT). It also has strong anabolic effects and milder androgenic and estrogenic effects
Brand names
Apart from the DIANABOL (also spelt DBOL), methandienone is also produced under a variety of brand names including VETANABOL, REFORVIT-B, NAPOSIM, METANABOL, DRONABOL, CHINLIPAN, AVERBOL and ANABOL among others. They are also available in multiple dosage variants as displayed in a variety of ads.
Generic names
Metandienone (or methandienone, the British approved name) is the generic and International Non-proprietary Name (INN) of DBOL. Scholars and scientists also refer to it as methandrostenolone and dehydro methyltestosterone, based on its chemical structure. The former synonym should not be confused with methandrostenolone, which is another name for methenolone (primobolan), a different AAS (Androgenic Anabolic Steroids) known.
History Of Dianobol
Metandienone was first described and synthesized by researchers in 1955 at the Chemische Industries Base (CIBA) laboratories in Basel, Switzerland. CIBA began marketing the medical drug in the United States under the name Dianobol in 1958. Originally, physicians prescribed the drug to burn victims and the elderly as a treatment for hypogonadism (which was given at a dosage of 5 to 10 mg/day in men and 2.5 mg/day in women) and androgen deficiency.
John Bosley Ziegler
Not a very long time after this, its off-label use as a performance enhancer to athletes in weight-lifting competitions emerged as it was introduced in the United States to university players by the American Olympic doctor John Bosley Ziegler as a response to Russian professional athletes who competed unfairly by utilizing injectable testosterone for amazing and instantaneous benefits.
John Bosley Ziegler was the Maryland-born doctor who introduced and developed steroids in America, particularly the anabolic steroid methandienone. He practised in Olney Md. specializing in handicapped and seriously injured patients while doing chemistry research for a company called CIBA, a pharmaceutical company based in Switzerland. He devoted his professional life studying steroids and would later introduce it to American bodybuilder representatives in the Olympics as the official team doctor.
Chemical Structure
Metandienone chemically referred to as 17α-methyl-δ1-testosterone or 17α- methylandrost-1,4-dien-17β-ol-3-one is a synthetic anabolic androstane steroid (AAS) and a 17α-alkylated derivative of testosterone. It is a modification of testosterone with a methyl at the C17-alpha position and a further covalent double bond between the C1 and C2 positions. The drug is additionally a boldenone (δ1- testosterone) 17α-methylated derivative and δ1 analogue of methyltestosterone (17α-methyltestosterone). Dianabol (Methandienone) is an anabolic androgen which means it most resembles the male hormone testosterone. Known to be taken orally, some labs tried to introduce it via injection but with little success. Due to its structure, this anabolic steroid is destroyed in the body when injected, hence ideal only if taken as a tablet.To make methandienone, early developers added the following modifications to the original testosterone:
- Add a methyl group as the 17th carbon
- Carbon 1 and carbon 2 covalent double bond
Pharmacology
Pharmacodynamics (What does the drug do to our body)
As an androgen analogue, methandienone binds to and activates the androgen receptor (AR) to produce its impact including a sudden increase in glycogenolysis, protein synthesis, and muscle strength over a short period. While it is often metabolized by 5α-reductase into methyl-1-testosterone (17α-methyl-δ1- DHT), a stronger AAS, the drug has extremely low affinity to this enzyme and methyl-1-testosterone is thus produced in minute amounts. As such, 5α- reductase inhibitors like finasteride and dutasteride will not reduce the DBOL’s androgenic impacts.
The ratio of Anabolic-Androgenic Activity
While the ratio of anabolic to androgenic activity of methandienone is becoming better relating to that of testosterone, the steroid still has androgenic activity and is still capable of causing virilization in women and the younger population. As such, it is only used and utilized by men. When subject to the aromatase enzyme through aromatization, methandienone can be metabolized into the estrogen methyl estradiol (17α-methyl estradiol). However, the estrogen produced is still resistant to degradation and hence methandienone still has its estrogenic activity causing the problems like gynecomastia (breast enlargement in men, also known as “man boobs”) and fluid retention. The co-administration of an anti-estrogen like an aromatase inhibitor such as anastrozole or a selective estrogen receptor modulator like tamoxifen can reduce or prevent these estrogenic problems. Metandienone has no progestogenic activity. And as with other 17α-alkylated AAS, methandienone greatly causes toxicity to the liver.
Pharmacokinetics (What does our body do to the drug)
Metandienone is easily absorbed by the body through oral administration. It has shown to have a very low affinity to human serum Sex Hormone Binding Globulin (SHBG), only about 10% of that of testosterone and around 2% to that of dihydrotestosterone. The steroid is metabolized within the liver by 6β- hydroxylation, 3α- and 3β-oxidation, 5β-reduction, 17-epimerization, and undergoes conjugation and among other reactions. Unlike methyltestosterone, because of the presence of its C1(2) covalent double bond, methandienone doesn’t produce 5α-reduced metabolites. The elimination half-life of methandienone is about 5-6 hours and is eliminated through the urine.
Research
Research in young adult male rats conducted by Hickson, Robert et al. was done separately and in combination to study the effects of anabolic steroid administration on body composition, organ weights, and high-intensity sprint running. Dianabol (methandrostenolone) administered 1 mg/day for 8 weeks had no significant effects on muscle weight or lean body mass in either the sedentary or trained animals. Meanwhile, the program of sprint training resulted in lower body weight, a lesser percentage of body fat (Sedentary at 13.5% vs. Runners at 8.5% vs. P<0.01) and a greater relative lean body mass (Sedentary at 86,5% vs. Runners at 91.5% P<0.01).
What Results Say?
From these results, researchers information concluded that (a) regular androgen levels in young, healthy male animals are already sufficient enough so that the addition of an extra dose of anabolic steroid does not anymore result in additional muscle growth stimulation and (b) the changes in body composition induced by short-duration and high-intensity sprint pieces of training are qualitatively almost the same to those results seen with endurance exercise training.
Dosage form
Metandienone is available in 2.5 and 5mg doses, in the form of oral tablets. It is usually given at a dosage of 5 to 10 mg/day in men and 2.5 mg/day in women during the androgen replacement therapy, as a treatment of hypogonadism. Since its discontinuation and withdrawal in most countries, including in the United States, use of it is now considered illegal.
Method of administration
Bodybuilding competitions mainly use this steroid for powerlifting and bodybuilding. Due to its quite short half-life of 5-6 hours, professionals recommend taking this steroid twice a day to guarantee that you will get a stable supply of it in your system. Further, in this dosing, this steroid is maximized since its concentration in the system does not anymore increase at one time (as mentioned, it reaches a plateau as part of the cycle).
Range of the Steroid Dosage Differs
When used in bodybuilding, these steroid dosages range from 10mg up to 50mg a day. Please remember that this steroid is not advisable in women due to its androgenic properties and other impacts. This steroid can be tolerated by many even without a meal but just to be safe, it is suggested to be taken after a meal should you prepare a cycle. Before exercising, the information is that the users can take the entire day quota of 50mg of metandienone for a brief period to prepare their bodies. By doing this, steroid advantages will be maximized at the optimal level.
DBOL Cycles
If you’re a newbie, it is generally not advised to take extremely heavy doses. Keeping the dosage lower (around 20mg to 25mg of metandienone every day) will suffice in the beginning days of the cycle. If you feel that you want to experience more quality results, you can even take up 30mg to 35mg per day. The combination of the steroids that you stack Dianabol with purely depends on the purpose of intake and the goals you want to attain. For example, bodybuilders and athletes have entirely different goals.
What do Bodybuilders Prefer?
Bodybuilders prefer a better physique, stronger and bulk muscles and to lower their fat levels. Athletes prefer improved stamina, endurance and power. Thus, the Dianabol cycle needs to be stacked up with other steroids with similar purposes.
Dosage
The maximum dosage information that is to be taken entirely depends on the particular individual. Some bodybuilders who have previously used it may say 35mg is already high enough for its maximum impact and outcomes and some, who are hard on themselves may say that you could go up to 50mg a day.
Onset of action
Within 3 days of usage, this steroid is detected in the body through various tests. You should stop using it for at least 3 months before testing, to avoid detection.
Gives Quick Results
It usually takes around five to seven days for the entire impacts to kick in. Because of its fast results, bodybuilders use this steroid as the initial step towards mass acquisition, as other commoners usually take a longer time to exhibit results. And just like any other steroidsout there, truth is that no matter how much you take in and the additional effort you exert in, there will come a point that its amount in your system plateaus. Well, not terrible because the moment it reaches the plateau, this is where the DIANABOL will begin to reveal its true action of slower efficiency that aid in the preservation of muscle gains.
Detection in body fluids
Metandienone undergoes extensive liver biotransformation by a variety of enzymatic pathways. The primary urinary metabolite is detectable for up to 3 days and a recently discovered hydroxymethyl end product can be found in urine for up to 19 days after a 5 mg single oral dose. Several of the methandienone metabolites are unique and hence methods for detection in urine samples usually involve gas chromatography-mass spectrometry.
Benefits of Dianabol
This steroid is very much popular among bulking season bodybuilders. As a steroid, it works by quickly filling up the muscles with water, a major component of muscles. Upon oral administration of this steroid, the user can quickly experience an increase in protein synthesis and a boost of nitrogen, essential for muscle size and strength.
Helps Gain Muscle Mass
It also prevents cortisol, a muscle eating hormone, from rising, making it easier to gain muscle mass. During its popular times in the 1950s, athletes would take a handful of this steroid daily to attain their mass goals.
Produces Muscle Gains
Aside from the fact that it can give significant muscle gains to its consumers, it can also be really good in enhancing one’s strength without losing fat deposits. this steroid accelerates glycogenolysis, the breakdown of glycogen into glucose, a simple sugar that the body uses to produce energy, which would only mean that the carb you take in will end up being extremely useful for constructing more muscles. Users taking this steroid also reported that became happier, motivated, and confident, all thanks to the rise in the male hormone we call testosterone. This steroid is the best steroid for rapid muscle gains and increased strength.
Some of the most preferred benefits of this steroid are as follows :
- It provides faster muscle gains more safely.
- Supplies your body with super strength and stamina.
- Offers great focus and drives to the user
- Provides rapid and better results (even in a month!)
- There is no need for an injection.
- Offers faster recovery times
- Reduces muscle fatigue
DBOL as a Kickstarter
This steroid is also commonly used to kickstart cycles with other compounds that take a relatively long time to take effect. For example, longer-acting testosterone such as Testosterone Enanthate or test Cypionate won’t kick in until about the second or third week.
Strength Gains By DBOL
In this case, this anabolic steroid is usually used as a Kickstarter to obtain the most out of the cycles. By the time the testosterone begins working, this steroid would already exhibit some considerable strength gains.
Drug Interactions
Intake of Dianabol along with other certain drugs may cause certain serious effects due to drug interactions. So, have a detailed discussion with your doctor regarding your medical history, previous prescriptions or any possible allergies that you have. Always strictly follow the instructions of your doctor.
Consult your Doctor
Precautions
DO NOT start, stop or alter the dosage of any of your drugs without consulting your doctor during the course of your Dianabol cycle.
This steroid is not usually advised to be used by women due to its risk of developing masculinizing problems.
Missing a Dose
If you forgot to take a dose of the medication, take it as soon as you remember. If you remembered that you have missed a dose only after 24 hours, skip the dosage and either continue with your next prescribed dose or consult with your doctor. It is better to consult with your doctor before taking your next dose. In any case, DO NOT take an extra dose of the medicine, unless you are asked to do so.
Side Effects
As it is considered to be an analogue of an androgen, adverse effects may occur due to the aromatization of the testosterone structure or due to the conversion into estrogen (female hormone).
Some of the most common side effects of the drug include :
- Virilism (A condition in which women exhibit masculine characteristics)
- Priapism (prolonged erection of the penis)
- Face acne
- Increased sexual desire
In addition to the above-mentioned side effects, Dianobol may cause certain other serious side effects in rare cases. They are not common, but it is better to be aware of all the possible outcomes. Some of them are :
- Increased calcium content in the blood
- Chances of cancer in the liver and prostate gland (along with an enlarged prostate)
- Visible water retention
- Leg cramps
- Difficulty in sleeping
- Night chills
- Diarrhoea and abdominal bloating
- An altered interest in sexual intercourse
- Excessive fat and bilirubin content in the blood
- Chances of heart attack or heart failure
- Lesser sperm count
- Yellowing of eyes or skin
- Depression or over excitement
- Aggressive behaviour
- Decrease in testicle size
- Darkening of skin
- Irritability
The common side effects of this steroid are associated with the inhibition of the natural development of testosterone. Users may conquer this problem by injecting exogenous testosterone, thereby maintaining healthy and normal levels of testosterone in the body. Side effects may be minimized by maintaining the prescribed dosages of the drug and by not exceeding the normal cycle of 6 weeks
Legal Status
After a U.S. amendment was passed in 1962, the FDA began reviewing the efficacy and safety of drugs that were approved before 1962, including DIANABOL. In 1965, CIBA was pressured by the FDA to investigate further its medical uses.
Strength Enhancer
As a result, this steroid was re-approved in treating osteoporosis in menopausal women and dwarfism. Further FDA pressures caused CIBA to withdraw this steroid from the U.S. market in 1983. Generic manufacturing also stopped following the drug’s withdrawal. Its non-medical use as a strength-enhancer and muscle-builder officially banned in the U.S. under the Anabolic Steroids Control Act of 1990. While methandienone is strictly regulated and no longer found its use in the U.S. formulary, it is still produced and medically used in some other countries such as in Mexico and Asia. As far as sports is concerned, authorities have restricted its usage throughout sports
Recent Times
Methandienone has found its way to nutritional supplements such as in the “1-T matrix” which can be purchased by telephone order. Metandienone, which is only available by special prescription from doctors with a special license, is not declared on the labels and concentrations vary from capsule to capsule.
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